Royal Air Force Typhoon fighter aircraft have operated alongside French warplanes in a combined operation targeting an hidden munitions depot in Syrian territory used by the IS group, per a report from the British defence ministry.
The site, identified by reconnaissance, was believed to be housing weapons and explosive materials, the statement said, and was situated in mountainous terrain just to the north of the ancient city of Palmyra in central Syria.
"Our aircraft utilized Paveway IV guided bombs to hit a series of approach shafts leading to the facility... initial indications are that the strike was effective," the ministry announced.
There was no evidence of any civilian impact in the attack conducted Saturday night and all the aircraft returned safely, the MoD added.
The Typhoon FGR4s were assisted by a Voyager aerial refuelling aircraft.
The Islamic State group - also known as ISIS - imposed militant control over significant areas in Iraq and Syria prior to its 2019 collapse.
"This action shows the UK's leading role, and resolve to stand shoulder to shoulder with allied nations, to eliminate any revival of IS and their violent and radical beliefs in the region," UK Defence Secretary the minister said.
British military aircraft have performed overwatch operations over Syria to "deter any efforts to regroup" of IS subsequent to its military defeat at the battle of Baghuz in the year 2019, the ministry said.
"I must thank the personnel of the UK armed forces involved in this operation for their skill and their courage," the Defence Secretary added. "Including them were thousands of British personnel stationed over Christmas and New Year. This action, to eliminate dangerous terrorists who threaten our way of life, shows how UK forces are always on standby, throughout the year, keeping Britain secure at home and influential overseas."
Last December, the United States armed forces conducted what it termed a "massive strike" on Islamic State objectives in the country, subsequent to an ambush killed two US troops and a local interpreter in Palmyra.
The UN reports Islamic State still maintains roughly 5-7 thousand combatants in Iraq and Syria.